November 2026
Absence of a Functional Human COX-3 Proteoform and Structural Basis for Canonical COX-1 Engagement by the Brain Paracetamol Metabolite AM404
No functional human COX-3 proteoform is detectable in public human multi-omic data, and the brain paracetamol metabolite AM404, not parent paracetamol, holds a stable channel-spanning pose in canonical human COX-1.
Research
Papers from the RS9 lab. Each one states its methods, its numbers and its limits, and links the manuscript in full.